MicardisPlus� in older patients with systolic hypertension, study confirms excellent efficacy and tolerability Part 3

Telmisartan be also market contained beside a few land by Abbott Laboratories, Bayer AG, GlaxoSmithKline, and Yamanouchi (now Astellas Pharma Inc.).

-- ATHOS*, a prospective, randomised, open-label, blind end-point evaluation hut, be designed to describe the blood hassle lower effects of MicardisPlus® (telmisartan 80mg plus hydrochlorothiazide 12.5mg) compare to a concurrence of amlodipine 10mg plus hydrochlorothiazide 12.5mg, in patients aged over and done with 60 years with isolated systolic hypertension (ISH). ISH was defined in the study in place of SBP ≥140mmHg, diastolic blood pressure (DBP) ≤95mmHg and 24-hour be motivated SBP measured by ABPM >125mmHg.3 -- The ATHOS study was fund by Boehringer Ingelheim.

-- Isolated systolic hypertension (ISH) take place when systolic blood pressure is elevated (≥140 mmHg), but diastolic blood pressure waste commonplace (≤90mmHg).9 -- MicardisPlus® reaper two antihypertensive agents, Micardis® and a thiazide diuretic, and is designate as second-line nurture in strut of far-reaching hypertension not suitably controlled by Micardis® monotherapy (EU and US) or HCTZ monotherapy (US).

This program is quantity of National Science Week, an initiative of the Australian Government.

3 Neldam S et al. Telmisartan plus Hydrochlorothiazide versus amlodipine plus hydrochlorothiazide in elder patients with predominantly systolic hypertension. Presented at American Geriatrics Society Annual Meeting, 12 May 2005.

Although the researchers shown the laboratory animals to dose of sildenafil and vardenafil that be comparable to the dose amount agreed for erectile dysfunction in human, here be no detectable cross effects in the rats, and neither drug increased transport of tracers into everyday psyche tissue.

5 National High Blood Pressure Education Program Working Group Report on Hypertension in the Elderly. National High Blood Pressure Education Program Working Group. Hypertension 1994; 23(3):275-285.

6 Sagie A et al. The inherent times of yore of borderline isolated systolic hypertension. N Engl J Med 1993; 329(26):1912-1917.

7 Williams B et al. The BHS Guidelines Working Party Guidelines for Management of Hypertension: Report of the Fourth Working Party of the British Hypertension Society, 2004 - BHS IV. J Human Hypertens 2004; 18: 139-185 8 Lacourcière Y et al. A comparison of the efficacy and duration of coup of angiotensin II receptor blocker telmisartan to amlodipine. Blood Press Monit 1998;3:295-302.

Next, all the participants were given 200 mg of Pycnogenol once a daytime for four weeks. After the repair point, participants' symptom and cramping episodes were recorded for one week short any Pycnogenol supplementation.

10 Weber M. The telmisartan Programme of Research tO salute Telmisartan End-organ proteCTION (PROTECTION). J Hypertens 2003; 21(6):S37-S46.